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Somatropin is a polypeptide hormone of recombinant DNA origin. Humatrope is synthesized in a strain of Escherichia coli that the addition of the gene has changed for human GH. The peptide comprises 191 amino acid residues and has a molecular weight of about 22,125 Daltons. The amino acid sequence of the peptide is identical to that of human GH of pituitary origin.